Crystal Structure of an Antipsychotic Agent, 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (Blonanserin).
نویسندگان
چکیده
منابع مشابه
Crystal structure of an antipsychotic agent, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (blonanserin).
both dopamine D2 and serotonin 5-HT2 receptor antagonist properties.1 In the chemical structure, this compound is different from all of the currently known antipsychotics, such as haloperidol, chlorpromazine and risperidone.2 To understand the structure-activity relationships of antipsycotics, an X-ray analysis of the title compound was undertaken. A colorless platelet crystal was obtained from...
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In the title compound, C13H13ClO4, the dihedral angle between the chloro-benezene ring and the least-squares plane through the 4-meth-oxy-2-oxobut-3-enoate ethyl ester residue (r.m.s. deviation = 0.0975 Å) is 54.10 (5)°. In the crystal, mol-ecules are connected by meth-oxy-ketone and benzene-carboxyl-ate carbonyl C-H⋯O inter-actions, generating a supra-molecular layer in the ac plane.
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ژورنال
عنوان ژورنال: Analytical Sciences
سال: 2002
ISSN: 0910-6340,1348-2246
DOI: 10.2116/analsci.18.1289